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Review and Analysis of the Overlapping Threats of Carbapenem and Polymyxin Resistant E. coli and Klebsiella in Africa

Harvard Dataverse (Africa Rice Center, Bioversity International, CCAFS, CIAT, IFPRI, IRRI and WorldFish)

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Title Review and Analysis of the Overlapping Threats of Carbapenem and Polymyxin Resistant E. coli and Klebsiella in Africa
 
Identifier https://doi.org/10.7910/DVN/JIJH3W
 
Creator Venne, Danielle M.
Hartley, David M.
Malchione, Marissa D.
Koch, Michala
Britto, Anjali Y.
Goodman, Jesse L.
 
Publisher Harvard Dataverse
 
Description Background:
Carbapenem-resistant Enterobacterales (CRE) are among the most serious antimicrobial resistance (AMR) threats. Emerging resistance to polymyxins raises the specter of untreatable infections. These resistant organisms have spread globally but, as indicated in WHO reports, the surveillance needed to identify and track them is insufficient, particularly in less resourced countries. This study employs comprehensive search strategies with data extraction, meta-analysis and mapping to help address gaps in the understanding of the risks of carbapenem and polymyxin resistance in the nations of Africa.

Methods:
Three comprehensive Boolean searches were constructed and utilized to query scientific and medical databases as well as grey literature sources through the end of 2019. Search results were screened to exclude irrelevant results and remaining studies were examined for relevant information regarding carbapenem and/or polymyxin(s) susceptibility and/or resistance amongst E. coli and Klebsiella isolates from humans. Such data and study characteristics were extracted and coded, and the resulting data was analyzed and geographically mapped.

Results:
Our analysis yielded 1341 reports documenting carbapenem resistance in 40 of 54 nations. Resistance among E. coli was estimated as high (>5%) in 3, moderate (1-5%) in 8 and low (
 
Subject Medicine, Health and Life Sciences
 
Date 2022-10-11
 
Contributor Venne, Danielle