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Plasma levels of TNF-α, IFN-γ, IL-4 and IL-10 during a course of experimental contagious bovine pleuropneumonia

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Title Plasma levels of TNF-α, IFN-γ, IL-4 and IL-10 during a course of experimental contagious bovine pleuropneumonia
 
Creator Sacchini, F.
Luciani, M.
Salini, R.
Scacchia, M.
Pini, A.
Lelli, R.
Naessens, Jan
Poole, Elizabeth J.
Jores, Joerg
 
Subject contagious bovine pleuropneumonia
cattle
 
Description Contagious Bovine Pleuropneumonia (CBPP), caused by Mycoplasma mycoides subsp. mycoides, is widespread in sub-Saharan Africa. The current live vaccine T1/44 has limited efficacy and occasionally leads to severe side effects in the animals. A better understanding of the immune responses triggered by Mycoplasma mycoides subsp. mycoides and their role in disease progression will help to facilitate the design of a rational vaccine. Currently, knowledge of cytokines involved in immunity and immunopathology in CBPP is rather limited. The aim of this study was to characterize the in vivo plasma concentrations of the cytokines TNF-alpha, IFN-gamma, IL-4, IL-10 and the overall role of CD4+ T cells in the development of cytokine levels during a primary infection. Plasma cytokine concentrations in two groups of cattle (CD4+ T cell-depleted and non-depleted cattle) experimentally infected with Mycoplasma mycoides subsp. mycoides were measured and their relationship to the clinical outcomes was investigated.
 
Date 2012-12
2012-05-03T08:33:18Z
2012-05-03T08:33:18Z
 
Type Journal Article
 
Identifier Sacchini, F., Luciani, M., Salini, R., Scacchia, M., Pini, A., Lelli, R., Naessens, J., Poole, J. and Jores, J. 2012. Plasma levels of TNF-α, IFN-γ, IL-4 and IL-10 during a course of experimental contagious bovine pleuropneumonia. BMC Veterinary Research 8:44.
1746-6148
https://hdl.handle.net/10568/16909
https://doi.org/10.1186/1746-6148-8-44
 
Language en
 
Rights CC-BY-2.0
Open Access
 
Publisher Springer Science and Business Media LLC
 
Source BMC Veterinary Research