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Resting-state fMRI in dementia patients

Harvard Dataverse (Africa Rice Center, Bioversity International, CCAFS, CIAT, IFPRI, IRRI and WorldFish)

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Title Resting-state fMRI in dementia patients
 
Identifier https://doi.org/10.7910/DVN/29352
 
Creator Mascali, Daniele
DiNuzzo, Mauro
Gili, Tommaso
Moraschi, Marta
Fratini, Michela
Maraviglia, Bruno
Serra, Laura
Bozzali, Marco
Giove, Federico
 
Publisher Harvard Dataverse
 
Description Low frequency fluctuations (LFFs) of the BOLD signal are a major discovery in the study of the resting brain by functional magnetic resonance imaging (fMRI). Two fMRI-based measures, functional connectivity (FC), a measure of signal synchronicity, and the amplitude of LFFs (ALFF), a measure of signal periodicity, have been proved to be sensitive to changes induced by several neurological diseases, including degenerative dementia. In spite of the increasing use of these measures, whether and how they are related to each other remains to be elucidated. In this work we used voxel-wise FC and ALFF computed in different frequency bands (slow-5: 0.01-0.027 Hz; slow-4: 0.027-0.073 Hz; and full-band: 0.01-0.073 Hz), in order to assess their relationship in healthy elderly as well as the relevant changes associated to Alzheimer's Disease (AD) and in Mild Cognitive Impairment (MCI). We found that in healthy elderly subjects FC and ALFF are positively correlated in anterior and posterior cingulate cortex, temporal cortex, and in a set of subcortical regions. No significant correlation was found between FC and ALFF in both AD and MCI patients. Notably, the loss of correlation between FC and ALFF in the AD group was primarily due to changes in FC rather than in ALFF. This finding indicates that the disease affects the coupling between FC and ALFF mainly toward
s a loss of global connection rather than towards a decrease of fluctuation amplitude.
 
Subject resting-state fMRI Alzheimer Mild Cognitive Impairment