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<span lang="EN-GB">Horse gram (</span><em><span lang="EN-GB">Macrotyloma uniflorum</span></em><span lang="EN-GB">) a traditional food medicine protects the kidney from the cisplatin-induced nephrotoxicity in albino rats</span><br />

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Title Statement <span lang="EN-GB">Horse gram (</span><em><span lang="EN-GB">Macrotyloma uniflorum</span></em><span lang="EN-GB">) a traditional food medicine protects the kidney from the cisplatin-induced nephrotoxicity in albino rats</span><br />
 
Added Entry - Uncontrolled Name A, Sudheer ; Raghavendra Institute of Pharmaceutical Education and Research
K, Somasekhar Reddy ; Raghavendra Institute of Pharmaceutical Education and Research
R, Jyothsna Naidu ; Raghavendra Institute of Pharmaceutical Education and Research
K, Vinay Kumar; Raghavendra Institute of Pharmaceutical Education and Research
S, Mahaboobjan ; Raghavendra Institute of Pharmaceutical Education and Research
P, Ramalingam ; National Institute of Pharmaceutical Education and Research (NIPER) - Hajipur
P, Likithasree ; Raghavendra Institute of Pharmaceutical Education and Research
 
Uncontrolled Index Term Cisplatin, Dolichos uniflorus Lam Kidney, Macrotyloma uniflorum seeds, Nephroprotective, Nephrotoxicity
 
Summary, etc. <p class="Normal1">The nutritional seeds from <em>Macrotyloma uniflorum</em> (MU) were studied for their unexplored beneficial effect in kidney diseases. Thus, the present study was designed to investigate the MU seed for its nephroprotective efficacy against cisplatin-induced nephrotoxicity in an animal model. The nephroprotective potential for the <em>Macrotyloma uniflorum </em>seed extract (MUSE) was evaluated in albino rats (250 and 500 mg/kg; p.o.) for 10 days. At the end of the study, the nephroprotective effect was assessed based on the levels of various biochemical parameters of serum, urine, and kidney tissue. The GC-MS analyses of extract confirmed the antioxidant phytochemical constituents responsible for the nephroprotective activity. The MUSE treatment at 250 and 500 mg/kg p.o. showed a significant reduction in the levels of blood urea nitrogen (p&lt;0.05), serum creatinine (p&lt;0.01), serum urea (p&lt;0.001), restore the urine volume (p&lt;0.01), and urine creatinine (p&lt;0.01) as compared to the negative control (cisplatin-injected rats). Subsequently, the abnormal conditions of creatinine clearance (p&lt;0.05) and serum albumin (p&lt;0.05) were restored to normal. For respective doses of 250 and 500 mg/kg p.o, the superoxide dismutase activity increased (p&lt;0.05) to 82.91 and 98.8 U/g whilst the glutathione level significantly increased (p&lt;0.01) to 36.24 and 46.17 µg/mg. Similarly, the catalase activity was significantly improved (p&lt;0.001) to 485.9 and 573.5 µM/g with a significant reduction (p&lt;0.001) in the level of the malondialdehyde to 84.56 and 68.56 nM/mg, respectively for low and high doses. The histopathology of kidney tissues confirmed the pronounced nephroprotection effect of MUSE against the cisplatin-induced injuries like tubular necrosis, hyaline cast, and vascular congestions. The major constituents found in GC-MS were inositol, ethyl alpha-d-glucopyranoside, n- hexadecanoic acid, 9, 12-octadecadienoic aci, 3-beta-stigmast-5-en-3-ol, Vitamin E, and stigmasterol. The results indicate the promising nephroprotective potential of <em>Macrotyloma uniflorum</em> seeds in nephrotoxicity induced rats, and the efficacy was comparable with vitamin E.</p><p class="normal"> </p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2023-12-18 16:39:14
 
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http://op.niscair.res.in/index.php/IJTK/article/view/43313
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 22, ##issue.no## 4 (2023): Indian Journal of Traditional Knowledge
 
Language Note en