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<p>Preclinical pharmacokinetics and herb-drug interaction studies of atorvastatin co-administered with the herbal slimming products</p>

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Title Statement <p>Preclinical pharmacokinetics and herb-drug interaction studies of atorvastatin co-administered with the herbal slimming products</p>
 
Added Entry - Uncontrolled Name Husain, Athar
Reza, Mohammad Irshad
Dadge, Shailesh
Syed, Anees A
Singh, Pragati
Verma, Saurabh
Katekar, Roshan
Kumar, Ashish
Gayen, Jiaur R.; CSIR-Central Drug Research Institute
 
Uncontrolled Index Term Atorvastatin, Cytochrome P450, Herb-drug interaction, HSPs, Metabolism
 
Summary, etc. <p>Herbal slimming products (HSPs) contain multiple herbs used in weight loss. Phytoconstituents of several plant extracts show the inhibitory effects on the drug-metabolizing enzymes causing interaction when taken with other drugs. Atorvastatin (ATS) is used in the treatment of hyperlipidemia. This study aimed to investigate the effect of HSPs on the pharmacokinetics and pharmacodynamics of ATS. ATS (10 mg/Kg) was administered alone or in combination with HSP1 (200 mg/Kg)/ HSP2 (165 mg/Kg) orally in the SD rats for pharmacokinetics study. Hyperlipidemia was induced in Golden Syrian Hamster by feeding HFD (60% kcal). Furthermore, biochemical levels in serum, ROS, gene expression and lipid accumulation levels were examined in hamster liver tissue. HSPs have significantly enhanced the permeability and inhibited the metabolism of ATS by inhibiting the CYP3A4 isoenzyme confirmed by <em>in vitro </em>assay. Co-administration of HSPs with ATS enhanced the relative bioavailability of ATS.Concomitant administration of HSPs with ATS has significantly reduced the fat content, inflammatory cytokines, TG, VLDL, LDL levels, tissue MDA level, HMGCR and SREBP1c mRNA expression levels, lipid accumulation as well as collagen content and has increased the serum HDL level as well as tissue SOD, CAT, GHS and mRNA expression levels of LXRα and CYP7A1. The aforementioned outcomes indicated that co-administration of HSPs with ATS may lead to herb-drug interaction. Therefore, precaution should be taken and dose adjustment is required when administered simultaneously.</p><p> </p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2023-12-18 16:39:14
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJTK/article/view/56004
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 22, ##issue.no## 4 (2023): Indian Journal of Traditional Knowledge
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJTK/article/download/56004/465582024
http://op.niscair.res.in/index.php/IJTK/article/download/56004/465582025
http://op.niscair.res.in/index.php/IJTK/article/download/56004/465582026
http://op.niscair.res.in/index.php/IJTK/article/download/56004/465582027
http://op.niscair.res.in/index.php/IJTK/article/download/56004/465582028