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The effect of <em>Nigella sativa</em> on serum levels of insulin-like growth factor and its binding proteins in postmenopausal women with low bone density: A triple-blind randomized controlled trial<br />

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Title Statement The effect of <em>Nigella sativa</em> on serum levels of insulin-like growth factor and its binding proteins in postmenopausal women with low bone density: A triple-blind randomized controlled trial<br />
 
Added Entry - Uncontrolled Name Abdolalipour, Somayeh ; Nutrition Research Center, Department of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, IR Iran.
Iranshahi, Amir Mehdi ; Nutrition Research center, Department of Clinical Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Amirpour, Mahdi ; Nutrition Research center, Department of Clinical Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Farshbaf-Khalili, Azizeh ; medicine and rehabilitation Research Centre, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
 
Uncontrolled Index Term IGF-1, IGFBPs, Menopause, Nigella sativa, Osteopenia, Osteoporosis
 
Summary, etc. <p>Animal studies have shown that <em>Nigella sativa</em> (<em>NS</em>) seed oil can increase Insulin-like growth factor (IGF-1) serum levels. This study aimed to investigate the effect of oral capsule <em>NS</em> on serum levels of IGF-1 and its binding proteins (IGFBP-1, IGFBP-3) in postmenopausal women with bone loss density. Sixty postmenopausal women of 50 to 65 years with bone loss density randomly received a soft capsule of <em>NS</em> oil 1000 mg or placebo once daily for six months with a 1:1 allocation ratio. DEXA method was used to measure bone density. Serum concentrations of IGF-1, IGFBP-1 and-3, ALT, AST, ALP, Cr, and urea were measured at baseline and after the intervention. There were no significant differences in serum levels of IGF-1, IGFBP-1, urea, Cr, ALT, AST, and ALP between the two groups at the end of six months. However, a significant increase has been shown in IGFBP-3 between groups after the intervention (Adjusted mean difference: 95% CI: 1.65: <br /> 0.36 to 2.97; p=0.013). We observed a significant increase in IGFBP-3 serum levels<strong> </strong>without any side effects. Additional research with an increased number of participants may be needed for further clarification of its beneficial anabolic effects on the GH system.<strong> </strong></p><p> </p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2023-12-18 16:39:14
 
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http://op.niscair.res.in/index.php/IJTK/article/view/49568
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 22, ##issue.no## 4 (2023): Indian Journal of Traditional Knowledge
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJTK/article/download/49568/465560694
http://op.niscair.res.in/index.php/IJTK/article/download/49568/465560695
http://op.niscair.res.in/index.php/IJTK/article/download/49568/465560696