The effect of <em>Nigella sativa</em> on serum levels of insulin-like growth factor and its binding proteins in postmenopausal women with low bone density: A triple-blind randomized controlled trial<br />
Online Publishing @ NISCAIR
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Title Statement |
The effect of <em>Nigella sativa</em> on serum levels of insulin-like growth factor and its binding proteins in postmenopausal women with low bone density: A triple-blind randomized controlled trial<br /> |
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Added Entry - Uncontrolled Name |
Abdolalipour, Somayeh ; Nutrition Research Center, Department of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, IR Iran. Iranshahi, Amir Mehdi ; Nutrition Research center, Department of Clinical Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran. Amirpour, Mahdi ; Nutrition Research center, Department of Clinical Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran. Farshbaf-Khalili, Azizeh ; medicine and rehabilitation Research Centre, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran. |
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Uncontrolled Index Term |
IGF-1, IGFBPs, Menopause, Nigella sativa, Osteopenia, Osteoporosis |
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Summary, etc. |
<p>Animal studies have shown that <em>Nigella sativa</em> (<em>NS</em>) seed oil can increase Insulin-like growth factor (IGF-1) serum levels. This study aimed to investigate the effect of oral capsule <em>NS</em> on serum levels of IGF-1 and its binding proteins (IGFBP-1, IGFBP-3) in postmenopausal women with bone loss density. Sixty postmenopausal women of 50 to 65 years with bone loss density randomly received a soft capsule of <em>NS</em> oil 1000 mg or placebo once daily for six months with a 1:1 allocation ratio. DEXA method was used to measure bone density. Serum concentrations of IGF-1, IGFBP-1 and-3, ALT, AST, ALP, Cr, and urea were measured at baseline and after the intervention. There were no significant differences in serum levels of IGF-1, IGFBP-1, urea, Cr, ALT, AST, and ALP between the two groups at the end of six months. However, a significant increase has been shown in IGFBP-3 between groups after the intervention (Adjusted mean difference: 95% CI: 1.65: <br /> 0.36 to 2.97; p=0.013). We observed a significant increase in IGFBP-3 serum levels<strong> </strong>without any side effects. Additional research with an increased number of participants may be needed for further clarification of its beneficial anabolic effects on the GH system.<strong> </strong></p><p> </p> |
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Publication, Distribution, Etc. |
Indian Journal of Traditional Knowledge (IJTK) 2023-12-18 16:39:14 |
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Electronic Location and Access |
application/pdf http://op.niscair.res.in/index.php/IJTK/article/view/49568 |
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Data Source Entry |
Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 22, ##issue.no## 4 (2023): Indian Journal of Traditional Knowledge |
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Language Note |
en |
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Nonspecific Relationship Entry |
http://op.niscair.res.in/index.php/IJTK/article/download/49568/465560694 http://op.niscair.res.in/index.php/IJTK/article/download/49568/465560695 http://op.niscair.res.in/index.php/IJTK/article/download/49568/465560696 |
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