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Evaluation of the antinociceptive effects of a selection of triazine derivatives in mice

Harvard Dataverse (Africa Rice Center, Bioversity International, CCAFS, CIAT, IFPRI, IRRI and WorldFish)

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Title Evaluation of the antinociceptive effects of a selection of triazine derivatives in mice
 
Identifier https://doi.org/10.7910/DVN/EMQHIO
 
Creator Valiollah Hajhashemi
Ghadamali Khodarahmi
Parvin Asadi
Hamed Rajabi
 
Publisher Harvard Dataverse
 
Description The authors showed in a previous study that some novel triazine derivatives
had an anti-inflammatory effect. The present study was designed to evaluate
the antinociceptive effect of five out of nine compounds including two vanillintriazine
(5c and 5d) and three phenylpyrazole-triazine (10a, 10b, 10e) derivatives
which showed the best anti-inflammatory effect.
Male Swiss mice (25–30 g) were used. To assess the antinociceptive
effect, acetic acid-writhing, formalin, and hot plate tests were used after intraperitoneal
injection of each compound.
 
Subject Medicine, Health and Life Sciences
Acute Pain
Analgesics
Anti-Inflammatory Agents
Heterocyclic Compounds
Mice
Pain Measurement
Triazines;
Vanillin
 
Contributor Nahm, Francis