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The role of Botulinum toxin type A related axon transport in neuropathic pain induced by chronic constriction injury

Harvard Dataverse (Africa Rice Center, Bioversity International, CCAFS, CIAT, IFPRI, IRRI and WorldFish)

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Title The role of Botulinum toxin type A related axon transport in neuropathic pain induced by chronic constriction injury
 
Identifier https://doi.org/10.7910/DVN/MCGNJT
 
Creator Bu, Huilian
Jiao, Pengfei
Fan, Xiaochong
Gao, Yan
Zhang, Lirong
Guo, Haiming
 
Publisher Harvard Dataverse
 
Description The mechanism of peripheral axon transport in neuropathic pain is still unclear. Chemokine ligand 13 (CXCL13) and its receptor (C-X-C chemokine receptor type 5, CXCR5) and GABA transporter 1 (GAT-1) play an important role in the development of pain. The aim of this study was to explore the axonal transport of CXCL13/CXCR5 and GAT-1 with the aid of the analgesic effect of botulinum toxin A (BTX-A) in rats.
Chronic constriction injury (CCI) rat models were established. BTX-A was administered to rats through subcutaneous injection. The pain behaviors in CCI rats were measured by paw withdrawal threshold (PWT) and paw withdrawal latencies (PWL). The levels of CXCL13/CXCR5 and GAT-1 were measured by western blots.
 
Subject Medicine, Health and Life Sciences
Axonal Transport
Botulinum Toxins, Type A
Chemokines
Colchicine
GABA Plasma Membrane Transport Proteins
Hyperalgesia
Neuralgia
Receptors, Chemokine
Sciatic Nerve
 
Contributor Nahm, Francis