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Replication Data for: Safety and efficacy of moderately high dose Turmacin supplementation on joint discomfort in healthy adults - a pilot proof of concept single arm study

Harvard Dataverse (Africa Rice Center, Bioversity International, CCAFS, CIAT, IFPRI, IRRI and WorldFish)

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Title Replication Data for: Safety and efficacy of moderately high dose Turmacin supplementation on joint discomfort in healthy adults - a pilot proof of concept single arm study
 
Identifier https://doi.org/10.7910/DVN/RXOJPK
 
Creator Raj, Jeffrey Pradeep
 
Publisher Harvard Dataverse
 
Description Objectives: The analgesic, anti-inflammatory and anti-arthritic properties of turmeric are usually attributed to the curcuminoids and the oil containing tumerones. Curcumin is also known to be beneficial in alleviating knee pain due to osteoarthritis. However, 69.4% of the turmeric rhizome contains Turmerosaccharides whose clinical benefit is still unexplored. Hence, this study aimed to assess the safety and efficacy of Turmerosaccharides on acute knee pain or discomfort upon exertion.
Methods: It was an open label, single arm interventional trial conducted from August 2018 – January 2019 in a tertiary care teaching hospital. Turmacin® / NR-INF-02 was administered to 15 healthy volunteers as 4 capsules of 500mg each of aqueous based extract of turmeric standardized to Turmerosaccharides (>10% w/w) for seven days. The stair mill at a speed of 60 steps per minute was used to induced knee pain and Visual Analogue Scale (VAS) was used to measure the pain intensity.
 
Subject Medicine, Health and Life Sciences
 
Contributor Raj, Jeffrey Pradeep