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Synergistic interaction between acetaminophen and L-carnosine improved neuropathic pain via NF-κB pathway and antioxidant properties in chronic constriction injury model

Harvard Dataverse (Africa Rice Center, Bioversity International, CCAFS, CIAT, IFPRI, IRRI and WorldFish)

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Title Synergistic interaction between acetaminophen and L-carnosine improved neuropathic pain via NF-κB pathway and antioxidant properties in chronic constriction injury model
 
Identifier https://doi.org/10.7910/DVN/4IFYKM
 
Creator Bamidele Victor Owoyele
Ahmed Olalekan Bakare
Olutayo Folajimi Olaseinde
Mohammed Jelil Ochu
Akorede Munirdeen Yusuff
Favour Ekebafe
Oluwadamilare Lanre Fogabi
Treister Roi
 
Publisher Harvard Dataverse
 
Description Inflammation is known to underlie the pathogenesis in neuropathic
pain. This study investigated the anti-inflammatory and neuroprotective mechanisms
involved in antinociceptive effects of co-administration of acetaminophen
and L-carnosine in chronic constriction injury (CCI)-induced peripheral neuropathy in
male Wistar rats.
Fifty-six male Wistar rats were randomly divided into seven experimental
groups (n = 8) treated with normal saline/acetaminophen/acetaminophen +
L-carnosine. CCI was used to induce neuropathic pain in rats. Hyperalgesia and allodynia
were assessed using hotplate and von Frey tests, respectively. Investigation
of spinal proinflammatory cytokines and antioxidant system were carried out after
twenty-one days of treatment.
 
Subject Medicine, Health and Life Sciences
Acetaminophen
Anti-Inflammatory Agents
Antioxidants
Carnosine
Cytokines
Hyperalgesia
Lipid Peroxidation
Neuralgia
NF-kappa B
Spinal Cord
 
Contributor Nahm, Francis