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Contrast-Enhanced Micro-Computed Tomography of Compartment and Time-Dependent Changes in Femoral Cartilage and Subchondral Plate in a Murine Model of Osteoarthritis

Harvard Dataverse (Africa Rice Center, Bioversity International, CCAFS, CIAT, IFPRI, IRRI and WorldFish)

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Title Contrast-Enhanced Micro-Computed Tomography of Compartment and Time-Dependent Changes in Femoral Cartilage and Subchondral Plate in a Murine Model of Osteoarthritis
 
Identifier https://doi.org/10.7910/DVN/FJCM6R
 
Creator Chan, Deva
 
Publisher Harvard Dataverse
 
Description In this study, we use contrast-enhanced micro-computed tomography (µCT) to establish a timeline of subchondral plate and cartilage changes in the murine femur after destabilization of the medial meniscus (DMM). We performed DMM or sham surgery in 10–12-week-old male C57Bl/6J mice. Femora were imaged using µCT after 0-, 2-, 4-, or 8-weeks. Cartilage-optimized scans were performed after immersion in contrast agent CA4+. Bone mineral density distribution (BMDD), cartilage attenuation, subchondral plate (SCP) and cartilage thickness and volume were measured, including lateral and medial femoral condyle and patellar groove compartments of the operated legs.
 
Subject Medicine, Health and Life Sciences
post-traumatic osteoarthritis, cartilage, subchondral plate, contrast-enhanced micro-computed tomography, murine model
 
Contributor Chan, Deva