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Data on mammary gland microRNA predicted gene targets and corresponding pathway analysis in female mice receiving flaxseed or its oil and secoisolariciresinol diglucoside components

Harvard Dataverse (Africa Rice Center, Bioversity International, CCAFS, CIAT, IFPRI, IRRI and WorldFish)

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Title Data on mammary gland microRNA predicted gene targets and corresponding pathway analysis in female mice receiving flaxseed or its oil and secoisolariciresinol diglucoside components
 
Identifier https://doi.org/10.7910/DVN/3ZNYES
 
Creator Wu, Diana
 
Publisher Harvard Dataverse
 
Description Breast cancer is one of the leading causes of cancer mortality in the world. A growing body of evidence demonstrates the association between flaxseed (FS) consumption and the reduction of breast cancer risk. Flaxseed (FS) is an oilseed rich in n-3 polyunsaturated fatty acids (PUFA), α-linolenic acid (ALA), in dietary phytoestrogen lignan, secoisolariciresinol diglucoside (SDG), and in fiber. Early-life exposure to FS or to its isolated components was associated with the improvement of the mammary gland (MG) morphogenesis and differentiation, and prevention of MG carcinogenesis. Here, we investigated the effect of FS as a whole food and its isolated oil (FSO) and lignan (SDG) on the MG microRNA (miRNA) signature, in female mice at a late stage of development. We identified a diet-specific MG miRNA signature. Significantly deregulated miRNAs in response to the 3-weeks intervention were associated with breast cancer. This data shows gene targets of these deregulated miRNAs identified using miRWalK, TargetScan, and miRdb, and associated enriched pathways identified using pathDIP for each diet.
 
Subject Medicine, Health and Life Sciences
 
Contributor Wu, Diana