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FAVOR Essential Database

Harvard Dataverse (Africa Rice Center, Bioversity International, CCAFS, CIAT, IFPRI, IRRI and WorldFish)

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Title FAVOR Essential Database
 
Identifier https://doi.org/10.7910/DVN/1VGTJI
 
Creator Zhou, Hufeng
Arapoglou, Theodore
Li, Xihao
Li, Zilin
Lin, Xihong
 
Publisher Harvard Dataverse
 
Description Functional Annotation of Variants - Online Resource (FAVOR, https://favor.genohub.org) is a comprehensive whole-genome variant annotation database and a variant browser, providing hundreds of functional annotation scores from a variety of aspects of variant biological function.

This FAVOR Essential Database is comprised of a collection of essential annotation scores for all possible SNVs (8,812,917,339) and observed indels (79,997,898) in Build GRCh38/hg38, including variant info, chromosome, position, reference allele, alternative allele, aPC-Conservation, aPC-Epigenetics, aPC-Epigenetics-Active, aPC-Epigenetics-Repressed, aPC-Epigenetics-Transcription, aPC-Local-Nucleotide-Diversity, aPC-Mappability, aPC-Mutation-Density, aPC-Protein-Function, aPC-Proximity-To-TSSTES, aPC-Transcription-Factor, CAGE promoter, CAGE, MetaSVM, rsID, FATHMM-XF, Gencode Comprehensive Category, Gencode Comprehensive Info, Gencode Comprehensive Exonic Category, Gencode Comprehensive Exonic Info, GeneHancer, LINSIGHT, CADD, rDHS.

These annotation scores can be integrated into FAVORannotator (https://github.com/zhouhufeng/FAVORannotator) to create an annotated GDS (aGDS) file by storing the genotype data and their functional annotation data in an all-in-one file. The aGDS file can then facilitate a wide range of functionally-informed downstream analyses.
 
Subject Computer and Information Science
Medicine, Health and Life Sciences
Functional Annotation
 
Language English
 
Contributor Zhou, Hufeng