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Whole-genome sequencing reveals new Alzheimer’s disease-associated rare variants - Rudy Tanzi, Lars Bertram and Win Hide

Harvard Dataverse (Africa Rice Center, Bioversity International, CCAFS, CIAT, IFPRI, IRRI and WorldFish)

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Title Whole-genome sequencing reveals new Alzheimer’s disease-associated rare variants - Rudy Tanzi, Lars Bertram and Win Hide
 
Identifier https://doi.org/10.7910/DVN/PMXTIX
 
Creator Morgan, Sarah
Tanzi, Rudy
Bertram, Lars
Hide, Win
 
Publisher Harvard Dataverse
 
Description Here we report the results of a family-based whole-genome sequencing (WGS) rare-variant association study in 2,247 subjects from 605 multiplex Alzheimer's disease (AD) families, followed by replication analyses in an independent case-control cohort comprising of more than 1,650 individuals. Employing both single-variant and spatial clustering-based (“region-based”) testing, we identified 13 new AD candidate loci (4 from single-variant, 9 from spatial-clustering analyses) that yield consistent rare-variant signals in both discovery and replication cohorts.
 
Subject Medicine, Health and Life Sciences
Alzheimer's disease
Whole-genome sequencing
 
Contributor Morgan, Sarah