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Influence of Escherichia coli lipopolysaccharide induced fever on the plasma kinetics of pazufloxacin in buffalo calves

Indian Agricultural Research Journals

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Title Influence of Escherichia coli lipopolysaccharide induced fever on the plasma kinetics of pazufloxacin in buffalo calves
 
Creator SHARMA, S K
ADITI, ADITI
UL HAQ, SHAH AHSAN
 
Subject Buffalo calves
Pazufloxacin
Dosage regimen
Fever
Pharmacokinetics
 
Description The pharmacokinetics of pazufloxacin was studied in healthy and febrile buffalo calves (5 mg/kg, IV). The fever was induced with Escherichia coli lipopolysaccharide. The drug concentration in plasma was detected by HPLC method. At 2.5 min the concentration of pazufloxacin in healthy and febrile animals were 17.8 0.6 µg/ml and 15.4±0.5 mg/ml, respectively and drug was detected up to 16 h. The distribution half-life of pazufloxacin increased from 0.09±0.01 h in healthy animals to 0.16±0.01 h in febrile animals. Drug distribution was altered by fever as febrile animals showed higher volume of distribution (1.35 0.09 L/ kg) higher than normal animal (1.03±0.06 L/kg). Total body clearances in healthy and febrile animals were 539.7±28.3 and 510.6±18.2 ml/kg/h, respectively. To maintain minimum therapeutic concentration of 0.1 µg/ml, a satisfactory dosage regimen of pazufloxacin in healthy and febrile buffalo calves would be 4.7 mg/kg and 4 mg/kg body weight, respectively, to be repeated at 12 h intervals.
 
Publisher Indian Council of Agricultural Research
 
Date 2014-02-12
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://epubs.icar.org.in/index.php/IJAnS/article/view/37836
10.56093/ijans.v84i2.37836
 
Source The Indian Journal of Animal Sciences; Vol. 84 No. 2 (2014); 166–169
2394-3327
0367-8318
 
Language eng
 
Relation https://epubs.icar.org.in/index.php/IJAnS/article/view/37836/16968
 
Rights Copyright (c) 2014 The Indian Journal of Animal Sciences
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