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Efeitos do tratamento do extrato metanólico de Baccharis dracunculifolia sobre alterações bioquímicas e histológicas de um modelo animal de diabetes.

Harvard Dataverse (Africa Rice Center, Bioversity International, CCAFS, CIAT, IFPRI, IRRI and WorldFish)

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Title Efeitos do tratamento do extrato metanólico de Baccharis dracunculifolia sobre alterações bioquímicas e histológicas de um modelo animal de diabetes.
 
Identifier https://doi.org/10.7910/DVN/8QAVEE
 
Creator Aparecido Pereira, Ricardo
 
Publisher Harvard Dataverse
 
Description Introduction: In recent years diabetes has been gaining major, standing out as a worldwide epidemic. It is a disorder characterized by hyperglycemia and is associated with several complications, dysfunction and failure of various organs. May result from defects in secretion and/or insulin action involving specific pathogenic processes. Due to the large number of cases , the disease causes a huge burden on the public purse. In this sense , special attention has been given to the different levels of disease prevention. To this end, several plant species have been used to treat and or combat the symptoms of diabetes mellitus . The present study utilized methanol extract of Baccharis dracunculifolia popularly known as broom or rosemary - of - field , is widely used in folk medicine . The infusion of the leaves is used for liver problems, stomach disorders and how antiinflammatory. Methods: 24 adult Wistar rats treated for 28 days were used. The animals were divided into 4 groups as follows: CS - Saline Control (treated with a solution of "Tween 80" and distilled water) CP - Control plant (treated with the extract of B. dracunculifolia); DS - Diabetic Saline (induced diabetes , treated with a solution of "Tween 80" and distilled water), SD - diabetic Plant (induced diabetes treated with extract of B. dracunculifolia) . The induction of diabetes was performed by administering 50 mg / kg streptozotocin (STZ). The animals were evaluated for weight gain. At 14◦ day of treatment the animals underwent OGTT, drop of blood flow. At the end of the treatment the animals were euthanized for withdrawal of blood samples and tissues for determination of biochemical parameters, hormonal and preparation of histological slides and quantification of TBARS via malondialdehyde in renal and hepatic tissue. Results and Discussion: There was statistical difference for the DS and DP groups parameters for creatinine (p
 
Subject Medicine, Health and Life Sciences
Diabetes
Herbal medicine
Baccharis
 
Contributor Aparecido Pereira, Ricardo