serum expression of lncRNA GAS5 and its effect
Harvard Dataverse (Africa Rice Center, Bioversity International, CCAFS, CIAT, IFPRI, IRRI and WorldFish)
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Title |
serum expression of lncRNA GAS5 and its effect
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Identifier |
https://doi.org/10.7910/DVN/OLLLC8
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Creator |
Ji, Juhua
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Publisher |
Harvard Dataverse
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Description |
The aim of the study was to explore the serum expression of long non-coding RNA (lncRNA) growth arrest-specific transcript 5 (GAS5) in Mycoplasma pneumoniae pneumonia (MPP) and its effect on LAMPS-induced apoptosis and inflammation. Totally, 56 children with MPP (MPP group) and 56 healthy children (NC group) were enrolled. The lncRNA GAS5 expression was measured by qRT-PCR. Serum levels of tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) were detected using ELISA, and the high mobility family protein B1 (HMGBl) was detected by qRT-PCR. The methylated binding protein 2 (MECP2) was inhibited by gene silencing, and the expression of MECP2, TNF-α, IL-6, HMGBl, p-p65, and p-IκBα was measured. The lncRNA GAS5 and TNF-α, IL-6, and HMGBl in the peripheral blood of the MPP group was positively correlated (P
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Subject |
Medicine, Health and Life Sciences
MPP, lncRNA GAS5, LAMPS, Apoptosis, Inflammatory factors, NF-κB |
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Contributor |
Ji, Juhua
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