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Replication Data for: Favorable effects, modes of use, and adverse reactions to cannabinoids in the management of autoimmune diseases: A scoping review.

Harvard Dataverse (Africa Rice Center, Bioversity International, CCAFS, CIAT, IFPRI, IRRI and WorldFish)

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Title Replication Data for: Favorable effects, modes of use, and adverse reactions to cannabinoids in the management of autoimmune diseases: A scoping review.
 
Identifier https://doi.org/10.7910/DVN/OYTBIH
 
Creator Teherán, Aníbal A.
Luis M. Pombo
 
Publisher Harvard Dataverse
 
Description Cannabinoids are coadjuvant drugs to treat chronic pain, fatigue, and spasticity symptoms in patients with autoimmune diseases[AImmDs]. We conducted a Scoping Review to provide an overview of the available evidence regarding the favorable effects, modes of use, and adverse drug reactions (ADRs) secondary to cannabinoids used as coadjuvant drugs for patients with AImmDs. Papers that estimated Cannabis, cannabinoids, or metabolites' effects on symptoms in AImmDs´ patients were retrieved, and data regarding specific cannabinoids, types [THC, CBD], drug presentation, administration route, outcomes measured, and adverse effects were described. 55 out of 71 papers were selected, 38 Randomized Clinical Trials[RCTs], and 17 Systematic Literature Reviews[SLRs], most focused in patients with Multiple Sclerosis (51/55;92.7%); Spasticity (29/55;52.7%), followed by pain (23/55;41.8%) were the primary outcomes. Sublingual route[spray] was used in half of the RCTs (19/38); Dizziness (14/19), vertigo (7/19), and dry-mouth (6/19) were the main ADRs described after the sublingual route. The ADRs overall risk, estimated with RR[95%CI] in patients with spasticity, ranged from 1.18[1.10-1.27] to 1.82[1.10-3.00], and estimated with OR[95%CI], ranged from 1.41[1.04-1.92] to 2.77[1.22-6.55]. The most favorable effects of cannabinoids were spasticity reduction, modulation of chronic pain, improvement of bladder function, and did not show a favorable effect on the quality of life. Finally, ADRs were primarily mild, reversible, and mainly affected the CNS (vertigo, dizziness, drowsiness, memory impairment, feeling of drunkenness, gait disturbance) and the gastrointestinal tract (dry mouth, nausea).
 
Subject Agricultural Sciences
Medicine, Health and Life Sciences
cannabinoids
autoimmune diseases
Dronabinol
Cannabidiol
rheumatic diseases
 
Contributor Teherán, Aníbal A.