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lncRNA GAS5 and its effect

Harvard Dataverse (Africa Rice Center, Bioversity International, CCAFS, CIAT, IFPRI, IRRI and WorldFish)

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Title lncRNA GAS5 and its effect
 
Identifier https://doi.org/10.7910/DVN/Q761FM
 
Creator Ji, Juhua
 
Publisher Harvard Dataverse
 
Description The aim of the study was to explore the serum expression of long non-coding RNA (lncRNA) growth arrest-specific transcript 5 (GAS5) in Mycoplasma pneumoniae pneumonia (MPP) and its effect on LAMPS-induced apoptosis and inflammation. Totally, 56 children with MPP (MPP group) and 56 healthy children (NC group) were enrolled. The lncRNA GAS5 expression was measured by qRT-PCR. Serum levels of tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) were detected using ELISA, and the high mobility family protein B1 (HMGBl) was detected by qRT-PCR. The methylated binding protein 2 (MECP2) was inhibited by gene silencing, and the expression of MECP2, TNF-α, IL-6, HMGBl, p-p65, and p-IκBα was measured. The lncRNA GAS5 and TNF-α, IL-6, and HMGBl in the peripheral blood of the MPP group was positively correlated (P
 
Subject Medicine, Health and Life Sciences
MPP, lncRNA GAS5, LAMPS, Apoptosis, Inflammatory factors, NF-κB
 
Contributor Ji, Juhua