Engineering Micro Oxygen Factory to Slow Tumor Progression by Hyperoxia Microenvironment
Harvard Dataverse (Africa Rice Center, Bioversity International, CCAFS, CIAT, IFPRI, IRRI and WorldFish)
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Title |
Engineering Micro Oxygen Factory to Slow Tumor Progression by Hyperoxia Microenvironment
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Identifier |
https://doi.org/10.7910/DVN/HJAESR
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Creator |
Wang, Weili
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Publisher |
Harvard Dataverse
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Description |
While hypoxia promotes carcinogenesis, tumor aggressiveness, metastasis, and resistance to oncological treatments, the impacts of hyperoxia on tumors are rarely explored because in vivo long-lasting oxygen supply is a big challenge. Herein, we constructed a micro oxygen factory, namely photosynthesis microcapsules (PMCs) by encapsulation of acquired cyanobacteria and upconversion nanoparticles in alginate microcapsules. This system enabled long-lasting oxygen supply by converting external radiations into red emissions for photosynthesis in cyanobacteria. PMC treatment suppressed NF-kB pathway, HIF-1α production and cancer cell proliferation. Hyperoxia microenvironments created by in vivo PMC implants inhibited hepatocarcinoma growth and metastasis, synergized the effects of anti-PD-1 in breast cancer. The engineered oxygen factory offers potential for tumor biology study in hyperoxia microenvironments and will inspire the exploration of oncological treatments.
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Subject |
Chemistry
Engineering Medicine, Health and Life Sciences |
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Contributor |
Wang, Weili
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