Record Details

Replication Data for: Coherent modeling of longitudinal causal effects on binary outcomes

Harvard Dataverse (Africa Rice Center, Bioversity International, CCAFS, CIAT, IFPRI, IRRI and WorldFish)

View Archive Info
 
 
Field Value
 
Title Replication Data for: Coherent modeling of longitudinal causal effects on binary outcomes
 
Identifier https://doi.org/10.7910/DVN/UZAI96
 
Creator Wang, Linbo
Meng, Xiang
Richardson, Thomas
Robins, James
 
Publisher Harvard Dataverse
 
Description Analyses of biomedical studies often necessitate modeling longitudinal causal effects. The current focus on personalized medicine and effect heterogeneity makes this task even more challenging. Towards this end, structural nested mean models (SNMMs) are fundamental tools for studying heterogeneous treatment effects in longitudinal studies. However, when outcomes are binary, current methods for estimating multiplicative and additive SNMM parameters suffer from variation dependence between the causal parameters and the non-causal nuisance parameters. This leads to a series of difficulties in interpretation, estimation and computation. These difficulties have hindered the uptake of SNMMs in biomedical practice, where binary outcomes are very common. We solve the variation dependence problem for the binary multiplicative SNMM via a reparametrization of the non-causal nuisance parameters. Our novel nuisance parameters are variation independent of the causal parameters, and hence allow for coherent modeling of heterogeneous effects from longitudinal studies with binary outcomes. Our parametrization also provides a key building block for flexible doubly robust estimation of the causal parameters. Along the way, we prove that an additive SNMM with binary outcomes does not admit a variation independent parametrization, thereby justifying the restriction to multiplicative SNMMs.
 
Subject Mathematical Sciences
Medicine, Health and Life Sciences
Bivariate mapping
Likelihood inference
Longitudinal studies
Variation independence
 
Contributor Meng, Xiang