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The effect of Nigella sativa on serum levels of insulin-like growth factor and its binding proteins in postmenopausal women with low bone density: A triple-blind randomized controlled trial

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Title The effect of Nigella sativa on serum levels of insulin-like growth factor and its binding proteins in postmenopausal women with low bone density: A triple-blind randomized controlled trial
 
Creator S, Abdolalipour
A M, Iranshahi
M, Amirpour
A, Farshbaf-Khalili
 
Subject IGF-1
IGFBPs
Menopause
Nigella sativa
Osteopenia
Osteoporosis
 
Description 805-814
Animal studies have shown that Nigella sativa (NS) seed oil can increase Insulin-like growth factor (IGF-1) serum levels. This study aimed to investigate the effect of oral capsule NS on serum levels of IGF-1 and its binding proteins (IGFBP-1, IGFBP-3) in postmenopausal women with bone loss density. Sixty postmenopausal women of 50 to 65 years with bone loss density randomly received a soft capsule of NS oil 1000 mg or placebo once daily for six months with a 1:1 allocation ratio. DEXA method was used to measure bone density. Serum concentrations of IGF-1, IGFBP-1 and-3, ALT, AST, ALP, Cr, and urea were measured at baseline and after the intervention. There were no significant differences in serum levels of IGF-1, IGFBP-1, urea, Cr, ALT, AST, and ALP between the two groups at the end of six months. However, a significant increase has been shown in IGFBP-3 between groups after the intervention (Adjusted mean difference: 95% CI: 1.65: 0.36 to 2.97; p=0.013). We observed a significant increase in IGFBP-3 serum levels without any side effects. Additional research with an increased number of participants may be needed for further clarification of its beneficial anabolic effects on the GH system.
 
Date 2023-12-20T10:32:17Z
2023-12-20T10:32:22Z
2023-12-20T10:32:17Z
2023-12-20T10:32:22Z
2023-12
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/63040
https://doi.org/10.56042/ijtk.v22i4.7205
 
Language en
 
Relation Int. Cl.23: A61K 36/00, A61K 39/395, A61K 19/10
 
Publisher NIScPR-CSIR,India
 
Source IJTK Vol.22(4) [October 2023]