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Horse gram (Macrotyloma uniflorum) a traditional food medicine protects the kidney from the cisplatin-induced nephrotoxicity in albino rats

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Title Horse gram (Macrotyloma uniflorum) a traditional food medicine protects the kidney from the cisplatin-induced nephrotoxicity in albino rats
 
Creator Sudheer, A
Reddy, K Somasekhar
Naidu, R Jyothsna
Kumar, K Vinay
Mahaboobjan, S
Likithasree, P
Ramalingam, P
 
Subject Cisplatin
Dolichos uniflorus Lam Kidney
Macrotyloma uniflorum seeds
Nephroprotective
Nephrotoxicity
 
Description 746-754
The nutritional seeds from Macrotyloma uniflorum (MU) were studied for their unexplored beneficial effect in kidney diseases. Thus, the present study was designed to investigate the MU seed for its nephroprotective efficacy against cisplatin-induced nephrotoxicity in an animal model. The nephroprotective potential for the Macrotyloma uniflorum seed extract (MUSE) was evaluated in albino rats (250 and 500 mg/kg; p.o.) for 10 days. At the end of the study, the nephroprotective effect was assessed based on the levels of various biochemical parameters of serum, urine, and kidney tissue. The GC-MS analyses of extract confirmed the antioxidant phytochemical constituents responsible for the nephroprotective activity. The MUSE treatment at 250 and 500 mg/kg p.o. showed a significant reduction in the levels of blood urea nitrogen (p
 
Date 2023-12-20T10:42:38Z
2023-12-20T10:42:38Z
2023-12
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/63048
https://doi.org/10.56042/ijtk.v22i4.7198
 
Language en
 
Relation Int Cl.23: A61K 36/00, A61K 45/06
 
Publisher NIScPR-CSIR,India
 
Source IJTK Vol.22(4) [October 2023]