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Effect of combination of radiotherapy and docetaxel on Cripto-1, β-catenin and DBC1 expression in breast cancer patients

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Title Effect of combination of radiotherapy and docetaxel on Cripto-1, β-catenin and DBC1 expression in breast cancer patients
 
Creator Zang, Tonglin
 
Subject Carbohydrate antigen CA15-3
Deletion gene 1
Tumor
 
Description 71-76
Among all cancer types, blood cancer tops in total number of
estimated cases and ranks fourth in fatalities caused by cancer.
Early diagnosis and treatment, particularly for breast cancer, may
prevent such fatalities to some extent. In this context, here, we have
explored the effect of docetaxel combined with radiotherapy on
cripto-1, β-catenin and DBC1 expression in breast cancer patients.
In this study, a total of 80 breast cancer patients treated in our
hospital from May 2017 to May 2020 were selected and divided
into 40 patients each in radiotherapy treatment group and docetaxel
combination group according to complete randomization method.
Patients in both groups were treated with conventional basic
therapy, patients with breast cancer were treated with radiotherapy
in the radiotherapy treatment group, and patients with breast cancer
were treated with docetaxel and radiotherapy in the docetaxel
combination group. Serum samples were analyzed by ELISA for
tumor markers: carbohydrate antigen CA15-3 (CA15-3),
glycoprotein CA125 (CA125), carcinoembryonic antigen (CEA);
the protein Cripto-1 (Cripto-1), β-catenin, deletion gene 1 (DBC1)
were detected by fluorescence quantitative PCR method (qPCR);
clinical efficacy as well as adverse effects were evaluated and the
cycle of breast cancer patient survival was counted. Compared
with radiotherapy treatment group, the levels of CA15-3, CA125,
CEA, Cripto-1, β-catenin and DBC1 in docetaxel combination
group were significantly decreased, with statistically significant
difference (P
 
Date 2023-12-26T11:08:38Z
2023-12-26T11:08:38Z
2023-12
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/63083
https://doi.org/10.56042/ijeb.v62i01.7444
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJEB Vol.62(01) [Jan 2024]