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Allium cepa L., a potential hepatoprotective and antituberculosis

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Title Allium cepa L., a potential hepatoprotective and antituberculosis
 
Creator Jadhav, Monika
Tatke, Pratima
 
Subject Antimicrobial
Antioxidant
In vitro antitubercular activity
In vivo hepatoprotective activity
Liver
Microplate alamar blue assay (MABA)
Red onion skin extracts
Tuberculosis
 
Description 37-48
The pharmacological effects of Allium cepa L., commonly known as onion, are attributed to its phenolic and flavonoid
compounds. In this study, we investigated the pharmacological properties of three varieties of onion (red onion, white onion,
and desiccated onion) by evaluating their antioxidant, antimicrobial, antitubercular and hepatoprotective activities. The
Soxhlet extraction technique with four solvents was employed to obtain a total of 28 extracts from the onion bulb, skin, and
dried powder. The extracts were subjected to various analyses, including yield determination, phytochemical testing,
measurement of total phenolic contents (TPC) and total flavonoid contents (TFC), as well as in vitro antioxidant assays such
as DPPH radical scavenging, hydroxyl radical scavenging, and superoxide radical scavenging methods. Additionally, in
vitro antimicrobial activity of the extracts was assessed against two Gram-positive bacteria, two Gram-negative bacteria, and
two fungi. The in vitro antitubercular activity was evaluated using the Microplate Alamar Blue Assay (MABA).
Furthermore, we investigated the in vivo hepatoprotective activity of the bioactive extracts by using paracetamol-induced
and isoniazid-rifampicin-induced hepatotoxicity models. Our results revealed that the red onion skin extracts exhibited
higher levels of TPC and TFC compared to other extracts. Additionally, the red onion skin extracts displayed promising
antioxidant and antimicrobial activity, while the red onion dry extracts showed significant antimicrobial and antitubercular
activity which was statistically tested at 5% significant level. Notably, the hydro-alcohol extract of red onion skin and the
ethyl acetate extract of dry red onion demonstrated notable antitubercular and hepatoprotective properties at P
 
Date 2023-12-26T11:23:14Z
2023-12-26T11:23:14Z
2023-12
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/63088
https://doi.org/10.56042/ijeb.v62i01.1420
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJEB Vol.62(01) [Jan 2024]