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Potential drug candidates against Hepatitis C virus: In silico screening of phytoconstituents from Phyllanthus fraternus G.L. Webster

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Title Potential drug candidates against Hepatitis C virus: In silico screening of phytoconstituents from Phyllanthus fraternus G.L. Webster
 
Creator Upadhyay, Richa
Tiwari, Kavindra Nath
 
Subject Blood brain absorption
CaCo2 permeability
Gulf leaf-flower
Human intestinal absorption
Liver
 
Description 17-27
Hepatitis C is a liver inflammatory disease caused by the Hepatitis C virus. Phyllanthus fraternus G.L. Webster,
commonly called Gulf leaf-flower, is an important medicinal plant and possesses hepatoprotective activity against hepatitis.
Here, we have determined and characterized the active ingredients from the leaf extract of P. fraternus by gas
chromatography-mass spectrometry (GC-MS) analysis. It resulted in the identification of fifteen compounds, which are the
first to be reported from P. fraternus. For finding the compounds responsible for HCV, identified compounds were docked
against important enzymes of HCV virus metabolism viz; HCVNS3 enzyme, HCVNS5, and hepatic damage indicator
enzymes AST and ALT. To ensure drug-likeness, the pharmacokinetic, physiochemical, and toxicity properties of the
compounds were also evaluated. The study has demonostrated the presence of seven hepatoprotective compounds alphacadinol,
elemol, 1,6-germacradien-5-ol, phytol, carissanol dimethyl ether, phyltetralin and 3-furanmethanol, alpha-(3,4-
dimethoxyphenyl) tetrahydro-3-hydroxy-4-veratryl- in the leaves extract of P. fraternus against the hepatitis C virus.
 
Date 2023-12-26T11:27:17Z
2023-12-26T11:27:17Z
2023-12
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/63090
https://doi.org/10.56042/ijeb.v62i01.4628
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJEB Vol.62(01) [Jan 2024]