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Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice

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Title Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice
 
Creator Menge, D.M.
Behnke, J.M.
Lowe, A.
Gibson, John P.
Iraqi, F.A.
Baker, R.L.
Wakelin, D.
 
Subject nematoda
mice
chromosomes
genetic maps
immunological factors
digestive system diseases
infection
genotypes
immunoglobulins [glycoproteins]
immunology
parasitology
 
Description This paper reports the results of a genome-wide search for quantitative trait loci (QTL) influencing immunological responses to infection with the gastro-intestinal nematode parasite Heligmosomoides polygyrus in an F2 population created by crossing the resistant SWR and the susceptible CBA inbred mouse strains. Following infections, intestinal granuloma score at post mortem, mucosal mast cell protease 1, and IgE and IgG1 titres were recorded. The susceptible CBA mice had significantly higher IgG1, but significantly lower IgE, mucosal mast cell protease 1 and granuloma scores than SWR mice. Significant QTL were mapped to chromosomes 4, 11, 13 and 17 for granuloma score; chromosomes 12 and 17 for IgE; chromosome 10, 17 and 18 for IgG1 and chromosomes 1, 9, 10, 11, 17 and 18 for mucosal mast cell protease 1. Chromosomes 10, 11, 17 and 18 had QTL affecting more than one trait, and these are most likely to represent single QTL with multiple effects rather than multiple QTL. Some of these QTL map to regions known to harbour genes responsible for the induction of immunological responses to intestinal worms.
 
Date 2003-06
2013-07-03T05:26:02Z
2013-07-03T05:26:02Z
 
Type Journal Article
 
Identifier Parasite Immunology;25(6): 341-349
0141-9838
https://hdl.handle.net/10568/33089
https://doi.org/10.1046/j.1365-3024.2003.00640.x
 
Language en
 
Rights Copyrighted; all rights reserved
Limited Access
 
Format p. 341-349
 
Publisher Wiley
 
Source Parasite Immunology