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Chemical composition and antioxidant activity of Acorus calamus L. accessions from different ecological niches

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Title Chemical composition and antioxidant activity of Acorus calamus L. accessions from different ecological niches
 
Creator Chaubey, Pinky
Parki, Archana
Nagarkoti, Kirti
Kumar, Ravendra
Prakash, Om
 
Subject Acorus calamus
Antioxidant
Essential oil
Molecular docking
β-asarone
 
Description 581-590
The essential oil composition of Acorus calamus (Acoraceae) rhizomes, collected from twenty different ecological
niches in Uttarakhand, India, with an oil yield ranging between 0.7–5.4% (v/w), was examined by GC/MS. Among the
identified components, β-asarone (62.3–75.9%), α-asarone (2.2–6.1%), Z-isoelemicin (2.4–6.2%), Z-methyl isoeugenol
(2.3–6.4%) and shyobunone (1.5–5.3%) were found to be the major ones. The antioxidant activity of different essential oils
was compared to that of standard antioxidants to assess their free radical scavenging potential, metal chelating ability, and
reducing power. The essential oils exhibited significant in vitro antioxidant activity. The IC50 values for DPPH radical
scavenging, metal chelating, and reducing ability exhibited by the rhizomes essential oils were observed between 22.28–
61.96 μg/mL, 29.55–159.26 μg/mL, and 21.41–61.19 μg/mL, respectively. Based on the above observations, the chemical
diversity of A. calamus essential oil can be a good source of herbal nutraceuticals and phenylpropanoids. The possible mode
of action and structure-activity relationship between major compounds of essential oils and proteins of antioxidant activity
were studied using in-silico molecular docking and were found to support the in-vitro results.
 
Date 2024-01-04T09:40:23Z
2024-01-04T09:40:23Z
2024-01
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/63160
https://doi.org/10.56042/ijnpr.v14i4.5912
 
Language en
 
Relation Int. cl. (2021.01)– A61K 36/00, A61K 125/00, A61P 39/00
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.14(4) [December 2023]