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In vitro evaluation of Elaeagnus conferta Roxb.- As a potent antioxidant and anti-inflammatory agent

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Title In vitro evaluation of Elaeagnus conferta Roxb.- As a potent antioxidant and anti-inflammatory agent
 
Creator Durairaj, Brindha
Dhanabal, Madhumitha
 
Subject Anti-inflammatory
Anti-oxidant assay
DPPH
Elaeagnus conferta
HRBC membrane stabilization
Protein denaturation assay
 
Description 573-580
The key objective of the study was to identify bioactive compounds present in Elaeagnus conferta Roxb. and to
determine their antioxidant and anti-inflammatory efficacy. Qualitative and quantitative preliminary screening of
phyto-constituents was carried out using different solvent extracts, namely petroleum ether, ethyl acetate, acetone, ethanol,
hydro-ethanol, and water, followed by in vitro antioxidant and anti-inflammatory assay. Among the six extracts,
hydro-ethanolic extract revealed the presence of most of the secondary metabolites, which was used for further analysis.
Antioxidant activity was determined by DPPH, Hydrogen peroxide scavenging assay and Nitric oxide scavenging assay.
The results showed significant antioxidant potential in a strongly dose-dependent manner. Based on the antioxidant results,
the in vitro anti-inflammatory assays were carried out. The anti-inflammatory assay inhibition of protein denaturation using
egg albumin, bovine serum albumin and HRBC membrane stabilisation was done, which revealed that this plant species
may serve as an excellent source of natural antioxidant and anti-inflammatory compounds. This study suggests that
E. conferta Roxb. has potent efficacy to act as an anti-inflammatory agent and can possibly be used as a plant source in the
pharmaceutical industry.
 
Date 2024-01-04T09:59:05Z
2024-01-04T09:59:05Z
2024-01
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/63161
https://doi.org/10.56042/ijnpr.v14i4.5414
 
Language en
 
Relation Int. cl. (2021.01) − A61K 36/00, A61K 127/00, A61P 29/00, A61P 39/00
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.14(4) [December 2023]