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Evaluation of wound healing and antimicrobial activity of root and whole plant of Byttneria herbacea Roxb. (Samarakhadyam)

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Title Evaluation of wound healing and antimicrobial activity of root and whole plant of Byttneria herbacea Roxb. (Samarakhadyam)
 
Creator Sharma, Tarun
Kumar, Vijay
Nariya, Mukesh
Acharya, Rabinarayan
 
Subject Antibacterial
Excision wound model
Gandhamardan hills
Pharmacological activity
Samarakhai
 
Description 564-572
Byttneria herbacea Roxb., family Sterculiaceae, a folklore herb commonly known as Samarakhai by the tribes of
Odisha, is traditionally used in treating wounds, wound infections and related ailments. The present study was carried out to
evaluate the antimicrobial and wound-healing activity of the root and whole plant of B. herbacea. The antimicrobial
potential of B. herbacea root (BHR) and B. herbacea whole plant (BHW) was screened against four Gram-positive and
Gram-negative bacterial strains: Staphylococcus aureus (ATCC 6538), Streptococcus pyogenes (ATCC 12384),
Pseudomonas aeruginosa (ATCC 9027), Klebsiella pneumoniae (ATCC 10031) and one fungal strain: Candida albicans
(ATCC 10231) which are predominantly responsible for wound infection. The antimicrobial activity was assessed by the
cylinder plate method. The wound-healing efficacy of BHR and BHW was evaluated in the excision wound model in albino
rats. BHR and BHW showed a good zone of inhibition against respective pathogens at higher concentrations. Both BHR and
BHW were found to possess significant wound-healing activity, evidenced by the increase in the rate of wound contraction
and skin-breaking strength, decrease in the period of epithelialisation, and increased hydroxyproline content. This study
revealed the wound-healing potential of B. herbacea in albino rats.
 
Date 2024-01-04T10:03:37Z
2024-01-04T10:03:37Z
2024-01
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/63162
https://doi.org/10.56042/ijnpr.v14i4.5893
 
Language en
 
Relation Int. cl. (2021.01)− A61K 36/00, A61K 125/00, A61P 17/00
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.14(4) [December 2023]