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Computational analysis of Linum usitatissimum-derived peptides: Toward therapeutic applications

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Title Computational analysis of Linum usitatissimum-derived peptides: Toward therapeutic applications
 
Creator Sunkar, Swetha
S, Archana V
H, Naveen Kumar
V, Hariharan
 
Subject Anticancer
Antimicrobial
Bioactive peptides
BIOPEP database
Flax seed
In silico
 
Description 542-555
The food proteome contains diverse bioactive peptides, each offering distinct health advantages for the cardiovascular,
nervous, immune, and gastrointestinal systems. This study researches the rich repository of bioactive peptides in flax seeds
(Linum usitatissimum), focusing on their potential health benefits across diverse physiological systems. Leveraging in silico
techniques, a comprehensive analysis of 11 protein sequences sourced from UniProt was conducted, utilising enzymatic
digestion to generate 160 non-repetitive, non-toxic peptides employing pepsin, trypsin, chymotrypsin, and combined
enzymatic strategies via BIOPEP database. The evaluated peptides were scrutinised for a spectrum of biological properties
encompassing antimicrobial, antitubercular, and anticancer attributes, alongside an investigation into their immunogenic
potential. Docking studies further elucidated the interactions between these peptides and their respective targets, shedding
light on their mechanisms of action. The findings unveiled a subset of peptides exhibiting substantial potential across
multiple properties, establishing flax seeds as a compelling source of bioactive peptides. This in silico predictive approach
serves as a vital precursor, offering cues for designing targeted experimental methodologies aimed at extracting therapeutic
peptides. The implications of this research extend to the development of functional foods or pharmaceuticals harnessing the
bioactive potential of flax seed-derived peptides for promoting human health and well-being.
 
Date 2024-01-04T10:13:39Z
2024-01-04T10:13:39Z
2024-01
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/63164
https://doi.org/10.56042/ijnpr.v14i4.6821
 
Language en
 
Relation Int. cl. (2021.01)− A61K 36/00, A61K 131/00, A61P 9/00, A61 31/00, A61K 35/00
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.14(4) [December 2023]