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Neuroprotective activity of aerial parts of Aeschynomene indica L. against scopolamine-induced memory impairment in rats

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Title Neuroprotective activity of aerial parts of Aeschynomene indica L. against scopolamine-induced memory impairment in rats
 
Creator Nimbal, S. K.
Ajagunde, Vaishnavi B.
 
Subject Aeschynomene indica L.
Memory
Neuroprotective
Rats
 
Description 533-541
Alzheimer's disease is the most common cause of dementia and death. The initial symptom is a gradually falling ability
to remember new information. Aeschynomene indica L. belongs to the family Leguminoseae and there is a lack of scientific
reports regarding its aerial parts on memory improvement. Hence our study was to investigate the ameliorative role of the
extract of aerial parts of A. indica against scopolamine-induced Alzheimer type disease in rats. The rats were divided into
five groups, with six animals each. Elevated plus maze and light and dark apparatus were used to assess learning memory
and acquisition memory, and an actophotometer was used to assess locomotor activity. In addition, biochemical parameters
were also estimated. The hippocampal lesions were studied utilizing an electronic microscope at 40X magnification. In the
scopolamine-treated group, escape latency time and locomotor activity were significantly elevated (P
 
Date 2024-01-04T10:18:05Z
2024-01-04T10:18:05Z
2024-01
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/63165
https://doi.org/10.56042/ijnpr.v14i4.7012
 
Language en
 
Relation Int. cl. (2021.01)− A61K 36/00, A61K 36/48, A61P 25/00
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.14(4) [December 2023]