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Evaluation of anaesthetic stress following administration of dexmedetomidine and its combinations with midazolam, fentanyl and ketamine in dogs

Indian Agricultural Research Journals

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Title Evaluation of anaesthetic stress following administration of dexmedetomidine and its combinations with midazolam, fentanyl and ketamine in dogs
 
Creator AHMAD, RAJA AIJAZ
AMARPAL, AMARPAL
KINJAVDEKAR, P
AITHAL, H P
PAWDE, A M
KUMAR, DINESH
 
Subject Dexmedetomidine
Dogs
Fentanyl
Midazolam
Stress indicators
 
Description The study was conducted on 16 apparently healthy adult dogs of either sex, randomly divided into 4 groups, each containing 4 animals. Animals of group A received dexmedetomidine (20 µg/kg) alone. Midazolam (0.2 mg/kg), fentanyl (4 µg/kg) + midazolam (0.2 mg/kg) and ketamine (10 mg/kg) + fentanyl (4 µg/kg) + midazolam (0.2 mg/kg) were administered along with dexmedetomidine (20 µg/kg) in the animals of groups B, C and D, respectively. All the drugs were given simultaneously by intramuscular route. Differential leucocytic count, plasma glucose, insulin and cortisol were measured at baseline (0 min) and at 30, 60 and 120 min after the drug administration. Neutrophilia was observed only for a very short period. Plasma insulin levels significantly decreased whereas a significant increase in the plasma glucose towards the end of the study period was observed except in group C in which it decreased. Cortisol levels were nonsignificantly lower than the base values throughout the study in all the groups. It could be concluded that dexmedetomidine and its combinations with midazolam, fentanyl and ketamine do not threaten homeostasis and can obtund the stress response associated with handling and anaesthetic procedures in dogs.
 
Publisher Indian Council of Agricultural Research
 
Date 2012-12-13
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://epubs.icar.org.in/index.php/IJAnS/article/view/25662
10.56093/ijans.v82i12.25662
 
Source The Indian Journal of Animal Sciences; Vol. 82 No. 12 (2012); 1495–1498
2394-3327
0367-8318
 
Language eng
 
Relation https://epubs.icar.org.in/index.php/IJAnS/article/view/25662/11867
 
Rights Copyright (c) 2014 The Indian Journal of Animal Sciences
https://creativecommons.org/licenses/by-nc-sa/4.0