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Plastic orchiectomy and some indicators of improvement of vital parameters and general condition of the organism in blood of the men with prostate cancer

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Title Plastic orchiectomy and some indicators of improvement of vital parameters and general condition of the organism in blood of the men with prostate cancer
 
Creator Kotrikadze, Nanuli
Khutsishvili, Eka
Alibegashvili, Manana
Ramishvili, Liana
Chigogidze, Teimuraz
Gabunia, Nino
 
Subject Androgen deprivation therapy
Antioxidant enzymes
Fatty acids
Lipid reprogramming
Phospholipids
Plastic orchiectomy
Prostate cancer
 
Description 39-47
Prostate cancer (PCa) is the most common malignancy affecting men in developed countries. Prostate gland cells,
normal or cancerous, are dependent upon androgens for survival and growth. Consequently, androgen deprivation therapy
(ADT) is still the mainstay for PCa treatment. Recent studies revealed that in comparison with pharmaceutical approaches,
surgical castration may be associated with significantly lower risks of peripheral arterial disease and cardiac-related
complications compared to chemical castration. Thus, our present research work aimed to investigate potential alterations in
lipid components, in particular the amount of phospholipids, cholesterol and free fatty acids in the blood of the men with
prostate adenocarcinoma before and after plastic orchiectomy in order to demonstrate the contribution of these changes in
PCa progression. We also studied the activities of antioxidant enzyme - superoxide dismutase (SOD) and prostatic acid
phosphatase (PAP) to estimate general condition of an organism. Revealed alterations in lipid spectrum components
(quantitative changes in the amounts of phospholipids, cholesterol, and fatty acids) before and after plastic orchiectomy
indicates on remodeling of lipid metabolism after plastic orchiectomy. Approximation of total cholesterol and phospholipids
levels to control group indices together with the reduced amounts of fatty acids indicates on the regression of the pathology
for a certain period of time (~6-18 months). Furthermore, increased activity of SOD and sharply reduced activity of acid
phosphatase after plastic orchiectomy must be the indicators for improvement of general condition of the body.
 
Date 2024-01-12T11:35:20Z
2024-01-12T11:35:20Z
2024-01
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/63192
https://doi.org/10.56042/ijbb.v60i12.5683
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.61(01) [January 2024]