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Interplay between NMDA receptor modulation and Na/K ATPase activity under the social isolation-induced stress in the hippocampus of male rats

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Title Interplay between NMDA receptor modulation and Na/K ATPase activity under the social isolation-induced stress in the hippocampus of male rats
 
Creator Burjanadze, George
Shengelia, Mariam
Tsverava, Lia
Mikadze, Mariam
Davitashvili, Elene
Solomonia, Revaz
Koshoridze, Nana
 
Subject Mg+-ATPase
Na+/K+-ATPase subunits
NMDA receptor
Oxidative stress
 
Description 32-38
Living organisms exhibit heightened susceptibility to prolonged social isolation, leading to the onset of diverse
pathological processes culminating in various diseases. The nervous system, notably sensitive to such alterations, may
manifest neurodegenerative changes. Of particular interest in these conditions is the role of neurotransmitters within the
central nervous system (CNS). Thus, our focus was directed towards the glutamate NMDA receptor, known for its pivotal
involvement in synaptic plasticity and memory regulation.
Understanding the interplay between glutamate and its receptors, notably the NMDA receptor, with the Na+/K+-ATPase -
an essential player in cellular homeostasis - remains insufficiently explored, especially under social isolation. Consequently,
our study aimed to elucidate this relationship within the male rat brain's hippocampus.
Experimental subjects underwent either 30 days of isolation or remained in a communal cage as control animals.
Assessing the expression levels of glutamate NMDA-receptor and Na+/K+-ATPase subunits via the western blot method.
Under prolonged social isolation, a surge in the phosphorylated NR2B subunits of the NMDA receptor indicated
heightened receptor activation. Simultaneously, a substantial reduction in Na+/K+-ATPase activity was observed, potentially
linked to decreased α1-subunit expression. These alterations hint at the NMDA receptor's activation and subsequent changes
triggered by elevated intracellular Ca2+ as likely causes for the diminished Na+/K+-ATPase activity amidst prolonged social
isolation.
 
Date 2024-01-12T11:38:36Z
2024-01-12T11:38:36Z
2024-01
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/63193
https://doi.org/10.56042/ijbb.v61i1.5286
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.61(01) [January 2024]