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Antitumor activity of Urtica dioica seed extract on diethylnitrosamine-induced liver carcinogenesis in rats

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Title Antitumor activity of Urtica dioica seed extract on diethylnitrosamine-induced liver carcinogenesis in rats
 
Creator Keleş, Ömer Faruk
Huyut, Zübeyir
Arslan, Mevlüt
Yıldızhan, Kenan
Yener, Zabit
 
Subject Biochemical markers
Diethylnitrosamine
Histopathology
Liver carcinogenesis
Rat
Urtica dioica
 
Description 16-31
Hepatocellular carcinoma (HCC) is a significant health problem for human life; therefore, new therapeutic approaches
are essential. In vitro studies have shown that the extract of Urtica dioica seed extract (UDSE) may be a crucial protective
agent to prevent HCC. Therefore, this study aimed to investigate the antitumor efficacy of UDSE in the process of
carcinogenesis induced by diethylnitrosamine (DENA). The antitumor efficacy was evaluated by examining liver tissue
histopathology and expression of Hep par-1, alpha-fetoprotein (AFP), caspase-3, and inducible nitric oxide synthase (iNOS)
in the liver tissue and activities/levels of aspartate transaminase (AST), alanine transaminase (ALT), lactate dehydrogenase
(LDH), carbohydrate antigen (CA) 15-3, CA 19-9, CA 125-II in the serum, and also total oxidative stress (TOS),
malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), total antioxidant
status (TAS) in the serum and liver. In addition, real-time PCR was used to evaluate the levels of tumor necrosis factoralpha
(TNF-α), interleukin (IL-1β, IL-6), and proliferating cell nuclear antigen (PCNA) in liver tissue. It was observed that
DENA application increased liver function tests, cancer markers, apoptosis, and proinflammatory cytokine levels, but UDSE
application and DENA suppressed these increases. The findings and histopathological data demonstrated that the UDSE has
a very significant antitumor efficacy on the process of DENA-induced hepatocellular carcinogenesis, which appears to be
attributable to its antioxidant, anti-apoptotic, and anti-proliferative activity.
 
Date 2024-01-12T11:42:42Z
2024-01-12T11:42:42Z
2024-01
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/63194
https://doi.org/10.56042/ijbb.v60i12.1469
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.61(01) [January 2024]