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In-vitro studies of bioactive nanoemulgel from agro-waste and mathematical modeling of drug release

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Title In-vitro studies of bioactive nanoemulgel from agro-waste and mathematical modeling of drug release
 
Creator V, Gaanapriya
V M, Sivakumar
M, Thirumarimurugan
 
Subject Agro-wastes
Bioactive component
Drug delivery
Release mechanism
 
Description 135-142
A comparison of the bioactive components present in the 1:16 (% w/v) ethanol extracts of rinds of Citrus limetta, Punica
granatum and leaves of Musa acuminata have been carried out. The leaf extract of Musa acuminata revealed the presence of
about 88% of components with antimicrobial activities. The current work focuses on a comparative study of fitness of
empirical (Zero, First, Higuchi) and semi empirical (Ritger-Peppas) mathematical models to describe the drug release
mechanism of the formulated nanoemulgel. In-vitro studies are carried out, of which B1 posed 96% of cumulative drug
release. The results revealed that Higuchi model fitted the best for the optimized formulation of B1, B2, and B3 with higher
regression coefficient (R2 values of 0.99). The formulation followed the Fickian type of release for the bioactive component,
which can be used for treating the fungal infection.
 
Date 2024-01-12T12:09:16Z
2024-01-12T12:09:16Z
2024-01
 
Type Article
 
Identifier 0975-0991 (Online); 0971-457X (Print)
http://nopr.niscpr.res.in/handle/123456789/63198
https://doi.org/10.56042/ijct.v31i1.7609
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJCT Vol.31(1) [January 2024]