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Reproductive Toxicity Induced by 5-Fluorouracil (5-FU) and the Potential Ameliorative Effects of Naringin in -28 Days Experimental Study in Wistar Rats

Indian Agricultural Research Journals

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Title Reproductive Toxicity Induced by 5-Fluorouracil (5-FU) and the Potential Ameliorative Effects of Naringin in -28 Days Experimental Study in Wistar Rats
 
Creator Sravathi Vemula
Jeevanalatha Mylaram
Swathi Bora
Nagarjuna Gandham
Mounika Kamishetti
Durga Veera Hanuman Donga
Bhaskar Debbarma
 
Subject Naringinin, testicular toxicity and inflammation
 
Description This study evaluates the potential ameliorative effects of Naringenin (NG) on testicular function in a 5-Fluorouracil (5-FU) induced testicular toxicity model. Male rats were divided into control, 5-FU treated, NG treated and NG + 5-FU combination groups with 6 animals each. Hormonal assays revealed a significant decrease in 5-FU treated group. Furthermore, pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) exhibited a marked increase in the 5-FU group, which was significantly attenuated by decrease pro-inflammatory levels in NG + 5-FU combination group. Anti-inflammatory cytokine (IL-10) levels significantly decreased in 5-FU group but were notably restored with NG treatment along with hormone levels by mitigating chemotherapy-induced testicular damage.
 
Publisher Indian Veterinary Association
 
Date 2024-01-19
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://epubs.icar.org.in/index.php/IVJ/article/view/147607
10.62757/IVA.2024.101.1.24-27
 
Source The Indian Veterinary Journal; Vol. 101 No. 01 (2024): January, 2024; 24-27
0974-9365
0019-6479
 
Language eng
 
Relation https://epubs.icar.org.in/index.php/IVJ/article/view/147607/53685
 
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