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Synthesis, characterization, antimicrobial, anti-diabetic, anti-inflammatory and anti-cancer studies of Schiff base metal(II) complexes derived from mixed Schiff base ligands

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Title Synthesis, characterization, antimicrobial, anti-diabetic, anti-inflammatory and anti-cancer studies of Schiff base metal(II) complexes derived from mixed Schiff base ligands
 
Creator Karthik, S
Priya, P
Gomathi, T
 
Subject Mixed ligand complexes
Anti-diabetic
Anti-cancer
Anti-inflammatory
 
Description 112-120
A new Schiff base with ligands (L1 and L2) has been prepared from cinnamaldehyde with aniline (L1) and 4-hydroxy-3-
methoxybenzaldehyde with o-nitroaniline in 1:1 molar ratio. The mononuclear metal(II) complexes [(ML1L2)] [M= Co(II),
Ni(II), Cu(II) and Zn(II)] have been synthesized and characterized. ML1L2 synthesized from ligand (L1), metal salts and
ligand (L2) molar ratio is 1:1:1. Elemental analyses, IR, NMR, Electronic spectra, SEM and molar conductivity have been
obtained to clarify the structure of synthesized metal(II) complexes. Square planar geometry is proposed for CoL1L2, NiL1L2
and ZnL1L2, and distorted square planar geometry for CuL1L2 complex. Antibacterial activity of metal(II) complexes,
ML1L2 have been tested against Gram(+) and Gram(–) bacteria and fungi. The anti-inflammatory and anti-diabetic actions
of the L1, L2, CuL1L2complexes have been studied. The anticancer activity of L1, L2 and CuL1L2
have been studied as
opposed to MCF-7 using MTT assay method.
 
Date 2024-01-23T09:48:11Z
2024-01-23T09:48:11Z
2024-01
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/63215
https://doi.org/10.56042/ijc.v63i1.4556
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.63(01) [Jan 2024]