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Synthesis, computational and biological activities of 2-[2-(4-arylamino)-4- methylphenylaminothiazol-5-oyl]naphthalenes

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Title Synthesis, computational and biological activities of 2-[2-(4-arylamino)-4- methylphenylaminothiazol-5-oyl]naphthalenes
 
Creator Jebalenet, J
Jenisha, J
Rosy, Bojaxa A
Reji, T F Abbs Fen
 
Subject Naphthalene
B3LYP/6-31G
DFT
SARS-CoVPLpro
Mulliken
DPPH
MTT
 
Description 72-79
2-[2-(4-Arylamino)-4-methylphenylaminothiazol-5-oyl]naphthalenes have been synthesized by the reaction of 2-
bromoacetyl naphthalene and 1-aryl-3-(N,N1-diarylamidino)thiourea in the presence of triethyl amine. The structures of the
newly synthesized analogues have been confirmed by spectroscopic techniques. The in vitro antioxidant activity has been
studied using DPPH assay and anticancer activity has been studied using MTT assay against cancer cells. In silico studies
have been performed to predict the binding modes of the compounds with the cyclin-dependent kinase protein 6WUU. It is
evident from the current results that all the synthesized compounds exhibit remarkable antioxidant and anticancer potential.
 
Date 2024-01-23T09:59:51Z
2024-01-23T09:59:51Z
2024-01
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/63219
https://doi.org/10.56042/ijc.v63i1.4424
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.63(01) [Jan 2024]