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Comparison of ketamine and propofol as maintenance agent for continuous intravenous infusion anaesthesia in water buffaloes

Indian Agricultural Research Journals

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Title Comparison of ketamine and propofol as maintenance agent for continuous intravenous infusion anaesthesia in water buffaloes
 
Creator MALIK, V
KINJAVDEKAR, P
AMARPAL, AMARPAL
AITHAL, H P
 
Subject Anaesthesia
Buffalo
Continuous intravenous infusion
Ketamine
Medetomidine
Propofol
 
Description The present study was conducted to compare the anaesthetic effects of ketamine and propofol as maintenance agents for continuous intravenous infusion anaesthesia in buffaloes. Clinically healthy adult male buffaloes (6), 2 to 3 year-old and weighing 290 to 325 kg, were used for repeated trials in 2 groups using medetomidine (2.5µg/kg) and butorphanol (0.05 mg/kg) intravenously as preanaesthetics. Induction of anaesthesia was achieved with 5% thiopental sodium in both groups. Anaesthesia was maintained with continuous intravenous infusion of ketamine (1%) in group K and propofol (1%) in group P. The treatments were compared by clinicophysiological, cardiorespiratory and haemodynamic parameters. Excellent sedation, analgesia and muscular relaxation were observed in both groups. Depression of palpebral and corneal reflex was higher in group P than in group K. Downward rotation of eye ball for longer time was observed in group P than in K group. Required mean infusion rates of ketamine and propofol to maintain the adequate depth of anaesthesia in groups K and P were 0.16±0.01 mg/kg/min and 0.05±0.00 mg/kg/min, respectively. The values of recovery time, sternal recumbency time and standing time did not differ significantly between the groups. Difference in heart rate was not significant up to 60 min of anaesthesia but after 70 min onwards HR in group K was significantly higher compared to groups P. Respiratory rate in groups K remained significantly higher during the maintenance period than in group P. Decrease in rectal temperature was significantly higher in group P than in K group. Mean arterial pressure in groups K remained significantly lower than in group P. Central venous pressure did not differ significantly between the groups. Haemoglobin oxygen saturation (SpO2) in group P remained significantly higher than in group K. Our results indicated that maintaining anaesthesia via continuous infusion of ketamine and propofol in buffaloes is a feasible, effective, and safe anaesthetic technique for surgical procedures of at least up to 2 h duration. Maintaining anaesthesia with propofol produced some depressive effects on cardiopulmonary parameters that were comparable to those associated with anaesthesia maintained by ketamine.
 
Publisher Indian Council of Agricultural Research
 
Date 2012-10-11
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://epubs.icar.org.in/index.php/IJAnS/article/view/24285
10.56093/ijans.v82i10.24285
 
Source The Indian Journal of Animal Sciences; Vol. 82 No. 10 (2012); 1156–1162
2394-3327
0367-8318
 
Language eng
 
Relation https://epubs.icar.org.in/index.php/IJAnS/article/view/24285/11516
 
Rights Copyright (c) 2014 The Indian Journal of Animal Sciences
https://creativecommons.org/licenses/by-nc-sa/4.0