Record Details

<p class="MsoNormal" style="margin-bottom: 0.0001pt; line-height: 200%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial; text-align: left;">Inhibition of Bungarus caeruleus snake venom toxicity by Citrus reticulata methanolic extract and in silico analysis of possible binding modes</p>

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Title Statement <p class="MsoNormal" style="margin-bottom: 0.0001pt; line-height: 200%; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial; text-align: left;">Inhibition of Bungarus caeruleus snake venom toxicity by Citrus reticulata methanolic extract and in silico analysis of possible binding modes</p>
 
Added Entry - Uncontrolled Name Raghavan, Srimathi ; Vellore Institute of Technology
Jayaraman, Gurunathan ; Vellore Institute of Technology
 
Uncontrolled Index Term Snakebite, Citrus aurantium, Citrus reticulata, Venom, Neutralization, Bungarus caeruleus
 
Summary, etc. <p>Snakebite envenomation has been one of the major causes of morbidity and mortality around the world. Though intravenous administration of commercial anti-venom systemically neutralizes the toxicity, adverse effects are commonly seen in the post-treatment period. Plant metabolites and their derivatives have been shown to exhibit a wide range of antiophidian properties. In this study, we have investigated the Bungaruscaeruleus venom neutralization potential of Citrus aurantium and Citrus reticulata Blanco peels in terms of phospholipase and hemolytic inhibition. Methanolic extract of C. reticulata exhibited the highest inhibition (93%) of PLA2 activity. However, the extracts of both these Citrus species significantly inhibited the hemolytic activity of the venom (54–82%). Molecular docking indicated the binding of the citrus metabolites to catalytic site residues (TRP19, GLY30, TYR31, GLY32, and HIS48) of PLA2 . In vivo studies using Swiss Albino mice confirmed the neutralising capacity of the citrus peel extract, as reflected by the increase in survival time. Therefore, the study reveals that these metabolites in the methanolic extract of the citrus peel can be used as supplements for the management of snake bites.</p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2024-01-29 14:34:37
 
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http://op.niscair.res.in/index.php/IJTK/article/view/49758
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 23, ##issue.no## 1 (2024): Indian Journal of Traditional Knowledge
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJTK/article/download/49758/465561209