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<p>Efficacy of a traditional herbal formula against drug-resistant childhood epilepsy</p>

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Title Statement <p>Efficacy of a traditional herbal formula against drug-resistant childhood epilepsy</p>
 
Added Entry - Uncontrolled Name Nematollahi, Mohammad Hadi ; Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran Department of Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Mansourinejad, Seyed Ebrahim ; Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
Ashrafzadeh, Farah ; Department of Pediatric Neurology, Mashhad University of Medical Sciences, Mashhad, Iran
Mehrabani, Mitra ; Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran
Akhondian, Javad ; Department of Pediatric Neurology, Mashhad University of Medical Sciences, Mashhad, Iran
Nazem, Esmaeil ; Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
Saravani, Mohsen ; Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Mehrbani, Mehrzad ; Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran
This study is was funded by Kerman University of Medical Sciences (grant No: 940675).
 
Uncontrolled Index Term Anacyclus pyrethrum, Child, Drug-resistant epilepsy, Paeonia lactiflora, Traditional medicine
 
Summary, etc. <p>In about one-quarter of childhood epilepsies, there is no complete response to the routine, available antiepileptic drugs (AEDs). In traditional Persian medicine (TPM), Paeonia lactiflora and Anacyclus pyrethrum have been known for their anticonvulsant effects. The aim of this study was to evaluate the therapeutic efficacy of a combined herbal formula consisting of the dried root of P. lactiflora and A. pyrethrum in childhood drug-resistant epilepsy (DRE). This single-arm before/after clinical trial was conducted on 46 children with DRE. The patients were observed for three months before as well as thirteen weeks after the administration of this traditional herbal preparation at a dose of 15 mg/kg/day. The frequency and duration of seizures were evaluated using the Hague seizure severity scale (HASS). There was a statistically significant reduction in both the frequency and duration of seizures after treatment with the herbal preparation (p-values were &lt;0.001 and &lt;0.05, respectively). A statistically significant response to the herbal formula started after eight weeks of treatment. The traditional formula of P. lactiflora and A. pyrethrum could be considered as a complementary medicine for treating childhood DRE. However, further studies are needed to provide more evidence of its benefits and possible harms and also determine the precise mechanisms of action of this formula as a medicinal remedy for epilepsy.</p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2024-01-29 14:34:37
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJTK/article/view/38767
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 23, ##issue.no## 1 (2024): Indian Journal of Traditional Knowledge
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJTK/article/download/38767/465520551
http://op.niscair.res.in/index.php/IJTK/article/download/38767/465520552
http://op.niscair.res.in/index.php/IJTK/article/download/38767/465520553
http://op.niscair.res.in/index.php/IJTK/article/download/38767/465520554
http://op.niscair.res.in/index.php/IJTK/article/download/38767/465520555