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Whole genome sequencing of Vibrio alginolyticus: Insights into virulence and antimicrobial resistance: Whole Genome Sequencing of Vibrio alginolyticus

Indian Agricultural Research Journals

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Title Whole genome sequencing of Vibrio alginolyticus: Insights into virulence and antimicrobial resistance: Whole Genome Sequencing of Vibrio alginolyticus
 
Creator Azhar Shahansha T. S.
mangottil, pradeep ayyappan
Krupesha sharma S. R.
Sanil N. K.
 
Subject Vibrio alginolyticus
genome sequence
virulence factors
antimicrobial resistance
 
Description Vibrio alginolyticus is a significant pathogen causing mortality and economic losses in mariculture and illness associated with human gastrointestinal disorders. This paper presents genome characteristics, comparative genome analysis, virulence factors, and antimicrobial resistance of a virulent V. alginolyticus strain (CMFRI-JF260912) isolated from diseased Asian seabass. A genome size of 5.05Mb consist of two circular chromosomes were revealed following genome sequencing using the Illumina HiSeq pipeline. Comparative analysis with other Vibrio species showed a close phylogenetic distance between CMFRI-JF260912 and Vibrio natriegens. Various virulence factors were identified, including genes related to adhesion, biofilm formation, quorum sensing, and toxin production. Four antimicrobial resistance genes namely tetracycline efflux Na+/H+ antiporter, Type B chloramphenicol Oacetyltransferase, carbenicillin-hydrolyzing class A beta-lactamase (CARB-42) and an oxytetracycline resistance phosphoribosyltransferase were also found. These findings enhance our understanding of the pathogenesis and antimicrobial resistance mechanisms of V. alginolyticus and offer valuable insights for mitigating Vibrio infections in aquaculture systems.
 
Publisher Society of Fisheries Technologists (India)
 
Date 2024-01-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://epubs.icar.org.in/index.php/FT/article/view/143865
 
Source Fishery Technology; Vol. 61 No. 1 (2024): Fishery Technology
2582-2632
0015-3001
 
Language eng
 
Relation https://epubs.icar.org.in/index.php/FT/article/view/143865/53740
 
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