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Molecular Insights into Actinobacterial Genome for Natural Product Discovery: Molecular Insights into Actinobacterial Genome

Indian Agricultural Research Journals

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Title Molecular Insights into Actinobacterial Genome for Natural Product Discovery: Molecular Insights into Actinobacterial Genome
 
Creator Das, Vineetha
Reshmi K.
Prinetha U. P.
K. V. Lalitha
Toms C. Joseph
 
Subject Actinobacteria
genome
biosynthetic gene cluster
secondary metabolites
 
Description Actinobacteria are gram positive and filamentous, is one of the dominant bacterial group and are of great economic importance. Actinobacteria are important sources of major bioactive compounds such as antibiotics, antifungals, immunosuppressants, antiviral, antitumor compounds, and enzymes. Streptomyces, one of the best characterized genus of the Actinomycetes and diverse with more than 600 species, is responsible for the synthesis of the twothird of the known active biomolecules. The genomes of the actinobacteria contains large gene clusters termed as biosynthetic gene clusters (BGCs) accountable for the synthesis of the secondary metabolites and most of the BGCs which are silent under the laboratory conditions are treasure sources of novel biomolecules. Here we review the important biosynthetic pathways underlying the synthesis of secondary metabolites.
 
Publisher Society of Fisheries Technologists (India)
 
Date 2024-01-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://epubs.icar.org.in/index.php/FT/article/view/144565
 
Source Fishery Technology; Vol. 61 No. 1 (2024): Fishery Technology
2582-2632
0015-3001
 
Language eng
 
Relation https://epubs.icar.org.in/index.php/FT/article/view/144565/53733
 
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