Record Details

Expressions of serum miR-146a and COX-2 in children with drug-resistant epilepsy and their correlation with prognosis

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Expressions of serum miR-146a and COX-2 in children with drug-resistant epilepsy and their correlation with prognosis
 
Creator Li, Hui
Chen, Bo
Zhao, Jie Feng
 
Subject Cyclooxygenase-2
MicroRNA-146a
 
Description 140-144
Epilepsy is one of the most common chronic diseases of
nervous system, and long-termanti-epileptic drug therapy leads to
drug-resistant epilepsy in few cases. MicroRNA-146a is reported
to influence development of drug-resistant epilepsy by regulating
inflammatory response. Similarly, cyclooxygenase-2 (COX-2) is
also known to play an important role in the early inflammatory
response and neural excitation of brain tissue under ischemic and
hypoxic conditions and alleviate epilepsy. Here, we investigated
the expression of serum miR-146a and COX-2 in children with
drug-resistant epilepsy and their correlation with prognosis. A
total of 173 children with epilepsy were selected and divided into
non-drug resistant group (110 patients) and drug-resistant group
(63 patients) according to the diagnostic standard of International
League Against Epilepsy (ILAE). All children with drug-resistant
epilepsy received hemispheric insular transection, the prognosis
was evaluated according to Engel classification, and the children
were divided into non-recurrence group (51 patients) and
recurrence group (12 patients) according to the 1-year follow-up
results. qRT-PCR and ELISA was used to detect the expression
level of miR-146a in serum and COX-2, respectively, and
compared between the two groups. Receiver operating
characteristic (ROC) curve was drawn to evaluate the predictive
value of serum miR-146a and COX-2 expression levels in drugresistant
epilepsy, and logistic regression analysis was used to
analyze the influencing factors of relapse in children with drugresistant
epilepsy. There were no significant differences in gender,
age, family history of epilepsy, course of disease and seizure
frequency between non-drug resistant group and drug-resistant
group (P >0.05); compared with those in the non-drug resistant
group, the expression levels of miR-146a and COX-2 in the drug
resistant group were higher (P
 
Date 2024-01-31T09:30:18Z
2024-01-31T09:30:18Z
2024-02
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/63272
https://doi.org/10.56042/ijeb.v62i02.8410
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.62(02) [Feb 2024]