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Polymorphism at 5UTR region of ACACB gene and its association with body weight and HDL concentration in layer chickens

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Title Polymorphism at 5UTR region of ACACB gene and its association with body weight and HDL concentration in layer chickens
 
Creator Ch, Shivaprasad
R, Vinoo
RN, Chatterjee
M, Muralidhar
D, Narendranath
K, Aswanikumar
 
Subject Genotyping
Haplogroup
High-Density Lipoprotein (HDL)
Obesity
Single Stranded Conformation Polymorphism (SSCP)
White Leghorn
 
Description 126-132
Understanding genetic regulation of adipose tissue developmental genes would help in designing healthy chicken for
human consumption. In the present study, we tried to identify the polymorphism at the 5UTR region of the Acetyl-CoA
Carboxylase Beta (ACACB) gene and its association with body weights and High-Density Lipoprotein (HDL) concentration
in IWI and IWK lines of White Leghorn layer chicken breed. A total of 500 birds comprising of 250 IWI line and 250 IWK
line were included in Single Stranded Conformation Polymorphism (SSCP) data analysis. Results revealed that in IWI lines
within group there is a significant (P ≤0.05) effect on body weights at 8th week and 16th week of age. Whereas, in IWK lines
within group there is a significant (P ≤0.05) effect on body weights at day old and 20th week of age was observed. In
general, the h8h8 haplogroup showed the highest body weights in both the lines. The association analysis of serum
concentration of HDL in IWI line revealed that h12h12 haplogroup birds was the highest (61.64±2.99) and in the h1h2
haplogroup it was found to be the lowest (42.72±7.23). In case of IWK, the h8h8 haplogroup birds were the highest
(62.47±6.06) serum concentration of HDL and in the h7h7 haplogroup, it was found to be the lowest (44.85±2.64) serum
concentration of HDL. In IWI lines within group, there is a non-significant (P ≤0.05) effect on serum concentration of HDL
and in IWK lines within group there is a significant (P ≤0.05) effect on serum concentration of HDL was observed. It is
concluded that promotor of the ACACB gene is highly polymorphic and have a significant effect on body weights and serum
concentration of HDL in White Leghorn layer chicken.
 
Date 2024-01-31T09:34:36Z
2024-01-31T09:34:36Z
2024-02
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/63274
https://doi.org/10.56042/ijeb.v62i02.2600
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.62(02) [Feb 2024]