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Preliminary in vitro evaluation of the cytoprotective effects of clarified açaí (Euterpe oleracea MART.) pulp on African green monkey kidney cells (VERO) treated with the antifungal fluconazole

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Title Preliminary in vitro evaluation of the cytoprotective effects of clarified açaí (Euterpe oleracea MART.) pulp on African green monkey kidney cells (VERO) treated with the antifungal fluconazole
 
Creator ALT, Pereira
TS, Santos
AC, Guimarães
NA, Muto
H, Rogez
RMR, Burbano
M de O, Bahia
 
Subject Antioxidant
Comet assay
Cyanidin 3-glucoside
Cytoprotective
Fluconazole
Fungal diseases
Genotoxic
Isoorientin
Microgel electrophoresis (MGE)
Single cell gel assay (SCG)
Water palm
 
Description 112-118
Açaí (Euterpe oleracea MART.) has been the target of several studies due to its strong antioxidant potential and possible
cytoprotective effect, thus providing health benefits to the population. Fluconazole is a widely known and used drug in the
treatment of fungal diseases. However, the literature shows that this drug can show cytotoxic effects, as well as cause DNA
damage. In this regard, the present study aims to assess the putative cytoprotective effect of clarified açaí (CA) pulp extract
on VERO cells exposed to fluconazole. It was observed in the MTT assay that CA was able to increase the viability of cells
exposed to the antifungal agent in three different times of exposure (24, 48 and 72 h). Similarly, the results of the comet
assay demonstrated that CA was able to decrease the genotoxic effects of fluconazole significantly. Thus, we conclude that,
under the assessed conditions, CA shows cytoprotective effects against the damage caused by fluconazole.
 
Date 2024-01-31T09:49:38Z
2024-01-31T09:49:38Z
2024-02
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/63276
https://doi.org/10.56042/ijeb.v62i02.2539
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.62(02) [Feb 2024]