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Antioxidant efficiency of Prunus laurocerasus L. fruit extract on doxorubicin induced hepatic and renal damage

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Title Antioxidant efficiency of Prunus laurocerasus L. fruit extract on doxorubicin induced hepatic and renal damage
 
Creator Cirrik, Selma
Hacioglu, Gulay
Cokeli, Emel Kabartan
Peker, Emine Gulceri Gulec
 
Subject Albumin
Cherry laurel
Creatinine
Glomerular filtration rate (GFR)
Kidney injury molecule-1 (Kim-1)
Liver
Neutrophil gelatinase-associated lipocalin (NGAL)
Oxidative stress
Reactive oxygen species (ROS)
Tissue damage
 
Description 103-111
In Turkish traditional medicine, the leaves, fruit and seeds of Prunus laurocerasus L., commonly called Cherry laurel,
are used to treat various diseases such as cancer, diabetes, influenza, tonsillitis and scalp dandruff. The medicinal value of
this plant can be attributed to its rich phenolic content and high antioxidant capacity. In this study, we investigated the
efficacy of P. laurocerasus (PL) fruit extract in reducing the hepatorenal side effects of doxorubicin (DOX). Sprague-
Dawley rats were divided into 4 groups as Control, DOX, PL500+DOX and PL1000+DOX (n=8). PL-extracts were given
perorally for two weeks (500 or 1000 mg.kg-1.day-1). After 48–h of DOX injection (15 mg/kg, i.p.), the animals were
sacrificed. Compared to control, in DOX group, we observed lower levels of serum albumin, higher alanine transaminase
(ALT), aspartate transaminase (AST) and creatinine levels (P
 
Date 2024-01-31T09:52:03Z
2024-01-31T09:52:03Z
2024-02
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/63277
https://doi.org/10.56042/ijeb.v62i02.4286
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.62(02) [Feb 2024]