Record Details

Protective effects of hydroalcoholic extract of Coronilla securidaca L. seeds on serum levels of plasma blood parameters, antioxidant status and liver tissue changes in tamsulosin treated rats

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Protective effects of hydroalcoholic extract of Coronilla securidaca L. seeds on serum levels of plasma blood parameters, antioxidant status and liver tissue changes in tamsulosin treated rats
 
Creator Motlagh, Sedigheh Khezri
Mokhtari, Mokhtar
Shariati, Mehrdad
 
Subject Alpha blockers
Antioxidants
Goat pea
Hatchet vetch
Hepatic transaminases
Liver
Tamsulosin
 
Description 93-102
The seeds of Goat pea or Hatchet vetch [Coronilla securidaca L. syn. Securigera securidaca (L.) Degen & Dörfl.] are rich in phenolic compounds and have many biological activities. Here, we tried to evaluate the protective effects of hydroalcoholic extract of C. securidaca seeds (HECS) on serum levels of blood plasma parameters, antioxidant status and liver tissue changes in tamsulosin (TAM) treated rats. Rats were divided in 9 groups of 8 each including control, sham, TAM0.4, HECS200, HECS400, HECS800, TAM0.4 + HECS200, TAM0.4 + HECS400 and TAM0.4 + HECS800. HECS and TAM were administered orally for 28 days. At the end of the study, to investigate the changes in blood plasma parameters and antioxidant status, serum levels of glucose, alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), albumin (Alb), total protein (TP), total bilirubin (TB), catalase (CAT), glutathione peroxidase (GPX) and superoxide dismutase (SOD) were measured. TAM0.4 administration significantly increased serum levels of glucose, ALT, AST, ALP and TB (P
 
Date 2024-01-31T11:26:40Z
2024-01-31T11:26:40Z
2024-02
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/63278
https://doi.org/10.56042/ijeb.v62i02.6513
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.62(02) [Feb 2024]